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Our laboratory focuses its activities on
the study of drugs (with special emphasis on anti-infective drugs) in a
broad context.
The Team consists of approx. 20 scientists,
4 technicians, and students
Research activities include:
Laboratory Researchexamines the interactions between antiinfective agents (mainly
antibiotics) and eucaryotic cells within a context of cellular and molecular
pharmacology and toxicology. Disciplines and methodologies used span
from Biophysics and Cellular and Molecular Biology to Morphology and
Animal Trials. New, original molecules are either designed and
synthesized or screened from natural sources
.
Clinical Research aims at improving the
use of antibiotics in the hospital set-up, based usually but not exclusively
on pharmacodynamic considerations and starting from original experimental
research in this area.
Educational activities
are undertaken within the context of the the Information Center on Infective Pathology
and Anti-infective Chemotherapy,
the Séminaire de Pathologie Infectieuse, the Belgian Antibiotic
Policy Coordination Committee, the Belgian Society of Infectiology and Clinical
Microbiology, and the International society for Antiinfective Pharmacology.
Chemotherapy
of intracellular infection (models of intracellular infections
for the evaluation of antibiotic cellular pharmacodynamics and cooperation
with cytokines)
Clinical Pharmacy (launched
in 2001)
This activity has now evolved on its own, while maintaining
strong links with our researcxh group
Please, visit the WEB site of the Centre
for Clinical Pharmacy (CFCL)
Expertise
(available for contract-based activities)
Laboratory research
in vitro studies of
drug-membrane interactions (biophysical and biochemical studies)
in vitro (cellular
models) of antibiotic activity in intracellular infections (cellular
pharmacokinetics and pharmacodynamics)
in vitro (cellular
and a-cellular models) and in vivo (animal models) evaluation
of antibiotic safety
rational design and synthesis
of new antimicrobials
phenotypic and genotypic
methods for the search of resistance by efflux in human pathogens
Clinical trials and assessment
of benefit/risk ratio of antibiotics:
pharmacodynamics and toxicodynamics-based
new approaches for antibiotic dosing
new drug trials
litterature and database
analysis (for registration and regulatory affairs purposes)
Educational
activities
workshop and
conferences on pharmacodynamics, resistance and appropriate choice
of antiinfective agents
interactive sessions
about the appropriate use of drugs for medical and pharmaceutical
audiences
private courses
for Industry
Publications
(asbtracts and full text available for the most recents)
The Unit is located on the campus of the
Health Sciences Sector (Secteur des Sciences de la Santé) of the
Catholic University of Louvain (Université catholique de Louvain)
in Brussels (Woluwé Saint-Lambert; approx. 10km [7 mi.] from the
city center).
Physical location: Building Van
Helmont [73], 1st floor
Postal address : avenue E. Mounier
73 bte B1.73.05, B-1200 Bruxelles, Belgium
(note the new postal mail box active as from July 2011)
within the Health
Science Sector (Faculties and Cliniques universitaires St-Luc
at Woluwé-St-Lambert): dial 4 and then only the last
4 digits (ex.: 4-7370)
from the University
main campus (Louvain-la-Neuve) or the campuses of St-Gilles and Mons:
dial 774 and the last 4 digits (ex.: 774-7370)
from anywhere else
in Belgium: dial 02 followed by the 7 digits number shown
hereunder (thus 9 digits in total; ex.: 02-7647370)
from outside Belgium:
dial your International Access Code (IAC) followed by 32
(Belgium), 2 (Brussels) and the the 7 digits number shown
hereunder (thus 10 digits in total after your IAC)
(example: IAC-32-2-7647370)
E-mails: as from July 2007,
the University uses the <first_name.last_name@uclouvain.be> addressing
system, which is in use for all addresses created since then.
However, all former addresses using <name@facm.ucl.ac.be> thatwere created before July 2007 are still working and can be used.
Scientific Staff
Senior investigators
(click on the name to get
a C.V.)
main
activities: secretarial and administrative tasks; microbiology,cell
culture, biochemistry and molecular biology support: Université
catholique de Louvain
Former Staff Members, Post-doctoral
fellows,Visiting Scientists, Doctoral fellows, Non-doctoral fellows, and Students
by chronological order of joining
the laboratory and with the following information by order: Name, degree when
joining the Unit, Country/State, period of stay, position(s)
held, main and/or final degree earned if any,
source(s) of financing
Former staff members
Guy Laurent, PhD, Belgium, 1981-1989 (Senior Investigator;Pharmaceutical
Industry)
Andrée Zenebergh, Pharm.D., Belgium, 1983-1990 (Senior Investigator;
IRSIA Research contract)
June
2020 :
Unusual thesis public defense: due to covid-19 pandemics and self-isolation
measures, the
public defense of Tiep Nguyen took place on line!
December
2016: Hussein
Chalhoub received a "bourse
du patrimoine" from the health science sector of the university to
continue his work on resistance by efflux in P. aeruginosa.
November
2016:Wafi
Siala and Françoise
Van Bambeke are interviewed by the Belgian Television (RTBF) for their
publication in Nature Communications
about the activity of the antifungal drug caspofungin against S. aureus biofilms.
See here the video
(36 MB; part of the Journal télévisé [Prime Time
News] of 4 November 2016).
See also a longer interview
on the private television network (RTL; wait for a few seconds and allow for
some ads before the story starts - if no longer available, open this .mpg
file [38 MB])
See also the article
published on line in the newspaper "La Libre Belgique"
(if no longer available download this PDF)
.
December
2011:Paul M. Tulkens is appearing at the Belgian Television at News Time
(Saturday 3 December; see video
[in French]) to comment about the use of antibiotics in relation to his participation
to the publication of a "Perspectives" paper in Nature Review of
Microbiology (Bush et al. Tackling
antibiotic resistance, Nature Reviews Microbiology (2011) 9:894-896).
.
May
2010: FEBS Youth Travel Fund
awarded to Hayet
Bensikaddour for her submission and presentation of an oral communication
and two posters (see details)
at the Workshop "Microbial Lipids, From Genomics to Lipidomics"
of the Federation of the European Biochemical Societies (FEBS), Vienna, Austria,
12-16 May 2010
September
2009:Travel grant awarded to
Sandrine Lemaire for attending the 49th Interscience Conference on
Antimicrobial Agents and Chemotherapy (ICAAC), San Francisco, CA, September
12-15, 2009, and presentation of 5 posters (see
details).
November
2002: Award
of the Société Belge d'Infectiologie et de Microbiologie
Clinique / Belgische Vereniging voor Infectiologie en Klinische Microbiologie
to Cristina Seral for the best poster (in the category "Poster already
presented at a major International Meeting" [ICAAC]). Mrs Seral is working
in the topic of Chemotherapy of
intracellular infection.
November
2000:Award of the Société Belge d'Infectiologie
et de Microbiologie Clinique / Belgische Vereniging voor Infectiologie en
Klinische Microbiologie to Stéphane Carryn for the best
original poster presented at its annual meeting. Mr Carryn is working in the
topic of Chemotherapy of intracellular infection.
December 1997:Award of the "GlaxoWellcome Grant" to Françoise
Van Bambeke, Research Associate [F.N.R.S.]. Dr Van Bambeke submitted
a grant application in the domain
of the Antibiotic efflux mechanisms.
